Pallavi symons biography definition
Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival
- Research article
- Open access
- Published:
BMC Medical Genomicsvolume 4, Article number: 49 (2011) Cite this article
12k Accesses
79 Citations
6 Altmetric
Metrics details
Abstract
Background
Glioblastoma is a complex multifactorial disorder that has swift and devastating consequences. Few genes have been consistently identified as prognostic biomarkers of glioblastoma survival. The goal of this study was to identify general and clinical-dependent biomarker genes and biological processes of three complementary events: lifetime, overall and progression-free glioblastoma survival.
Methods
A novel analytical strategy was developed to identify general associations between the biomarkers and glioblastoma, and associations that depend on cohort groups, such as race, gender, and therapy. Gene network inference, cross-validation and functional analyses further supported the identified biomarkers.
Results
A total of 61, 47 and 60 gene expression profiles were significantly associated with lifetime, overall, and progression-free survival, respectively. The vast majority of these genes have been previously reported to be associated with glioblastoma (35, 24, and 35 genes, respectively) or with other cancers (10, 19, and 15 genes, respectively) and the rest (16, 4, and 10 genes, respectively) are novel associations. Pik3r1, E2f3, Akr1c3, Csf1, Jag2, Plcg1, Rpl37a, Sod2, Topors, Hras, Mdm2, Camk2g, Fstl1, Il13ra1, Mtap and Tp53 were associated with multiple survival events.
Most genes (from 90 to 96%) were associated with survival in a general or cohort-independent manner and thus the same trend is observed across all clinical levels studied. The most extreme associations between profiles and survival were observed for Syne1, Pdcd4, Ighg1, Tgfa, Pla2g7, and Paics. Se
Encyclopedia of Life Writing: Autobiographical and Biographical Forms [2 vols., 1 ed.] 157958232X, 9781579582326
Table of contents :
Dedication
Contents
Editor’s Note
Board of Advisers
Contributors
Alphabetical List of Entries
Thematic List: Entries by Category
Encyclopedia of Life Writing
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
R
S
T
U
V
W
X
Y
Z
Index
Notes on Advisers and Contributors
Citation preview
ENCYCLOPEDIA OF LIFE WRITING Edited by Margaretta Jolly Precautionary measures such as physical distancing, wearing a mask, and hand hygiene to suppress virus transmission necessitated a shift in the communication paradigm.The study aimed to check the effects of wearing masks (N95, surgical, and cloth) due to the COVID-19 pandemic on interpersonal communication in audiology-speech-language pathology clinical setup from a clinician perspective. A total of 105 participants, 17 males, and 88 females, in the age range of 19 to 29 years (Mean age = 21.41 years; S.D = 1.6), participated in the study. A questionnaire consisting of 15 close-ended questions grouped into five major categories, Communication Effectiveness (3 questions), Visual Cues (5 questions), Physiological Effect (4 questions), Palliative Effect (1 question), and Environment Effect (2 questions) was framed. Procedure: Participants rated the questions using a binary forced-choice as either Yes or No adapted into a google form. Results showed that most questions in all five categories received an above-average “yes” response. A significant association between questions in communication effectiveness with visual cues and physiological effects was noticed, leading to the conclusion that wearing face masks impacted overall communication by affecting various parameters of speech, majorly, the voice. It was also seen that of all the participants, 60% used N95, 32.4% used cloth, and only 7.6% used surgical face masks. Speech-language pathologists have a significant role in facilitating oral/ verbal communication when such barriers are encountered in clients with communication disorders and fellow professionals with strategies to strengthen oral/ verbal communication. Keywords: ASLP, Face masks, Clinical set-up, Interpersonal communication, COVID-19 The Coronavirus disease (COVID-19) was defined by World Health Organization (WHO) as .
Encyclopedia of Life Writing Autobiographical and Biographical Forms
Edited by Margaretta Jolly
ISBN 978-1-57958-232-6
,!7IB5H9-ficdcg! www.routledge.com an informa business
Encyclopaedia Prelims 1
29/6/2001
2:18 pm
Page i
encyclopedia of
Life Writing Autobiographical and Biographical Forms
Volume 1
Encyclopaedia Prelims 1
29/6/2001
2:18 pm
Page ii
Page Intentionally Left Blank
Encyclopaedia Prelims 1
29/6/2001
2:18 pm
Page iii
encyclopedia of
Life Writing Autobiographical and Biographical Forms
Volume 1 A–K Editor Margaretta Jolly
FITZROY DEARBORN PUBLISHERS london · chicago
Encyclopaedia Prelims 1
29/6/2001
2:18 pm
Page iv
Copyright © 2001 by fitzroy dearborn publishers All rights reserved including the right of reproduction in whole or in part in any form. For information write to: fitzroy dearborn publishers 919 North Michigan Avenue, Suite 760 Chicago, Illinois 60611 USA or 310 Regent Street London w1b 3ax England
British Library and Library of Congress Cataloguing in Publication Data are available ISBN 1–57958–232–x
First published in the USA and UK 2001 Typeset by Regent Typesetting, London Printed and bound by Edwards Brothers Cover design by Hybert Design Cover illustration: M.C. Escher’s Drawing Hands © 2001 Cordon Art B.V., Baarn, Holland. All rights reserved.
Encyclopaedia Prelims 1
29/6/2001
2:18 pm
Page v
To my parents
Encyclopaedia Prelims 1
29/6/2001
2:18 pm
Page vi
Page Intenti Impact of Facemasks Use on Interpersonal Communication in a Clinical Setup: A Questionnaire Based Study
Abstract
Introduction